DESCRIPTION:DNMT3b,adenovoDNAmethyltransferase,isessentialindevelopmentandcanmediategenesilencing.Overexpressionand/orgeneamplificationofDNMT3b,alongwithDNAhypermethylation,havebeenobservedinanumberofcancers,suggestingthatDNMT3bisanoncogeneandapromisingtherapeutictarget.Forexample,DNMT3bexpressionandDNAmethylationareelevatedinasubsetofbreastcancersandbothspecificknockdownofDNMT3bexpressionandchemicalinhibitionofDNMTsenhancethesensitivityofbreastcancerlineswiththishypermethylationphenotypetocytotoxicchemotherapyagents.
ACCESSION#:NM_006892
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INCLUDESAMINOACIDS:2-853(C-term.)
TAG(S):N-GST
MW:121.6kDa
EXPRESSIONSYSTEM:Insectcell/Baculovirus
SUPPLIEDAS:Solutionofpurifiedrecombinantproteinin50mMTris/HClpH8.0,150mMNaCl,3mMDTT,10%glycerol(v/v).
STORAGE:-80°C,aliquotandsnap-freezeafterfirstuse.
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