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商品详细Reaction Biology/BIX-01294/EI-HMT-003
Reaction Biology/BIX-01294/EI-HMT-003
Reaction Biology/BIX-01294/EI-HMT-003
商品编号: EI-HMT-003
品牌: reactionbiology
市场价: ¥1960.00
美元价: 1176.00
产地: 美国(厂家直采)
公司:
产品分类: 反应底物
公司分类: Reaction_substrate
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商品介绍
BIX-01294 3HCl 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride

BIX-01294 is a selectiveinhibitor of G9a histonemethyltransferase (G9aHMTase; IC50 = 1.7 µM) as wellas GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9Me2(histone H3 lysine 9 methylation) invitro. It facilitatesthe reactivation of pluripotency genes and induces passive demethylation, thuspromoting reprogramming.BIX-01294, in combination with BAY K8644 (a calcium channel agonist),was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infectedneural progenitor cells. Itinduced apoptosis and decreased proliferation, mobility and invasion in humanneuroblastoma cells.

Physical Properties: Off-whitecrystalline powder

MW=600.0 C28H38N6O2· 3HCl

Analysis: >98% (HPLC); NMR(Conforms)

Solubilization: May be dissolved in water (50 mg/ml); or DMSO (50 mg/ml)

Storage: Store desiccated assupplied at ambient for up to 2 years. Store solutions at -20°C for up to 3 months.

Amount: 5mg

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