UNC-2170
3-Bromo-N-(3-(tert-butylamino)propyl)benzamide,hydrochloride
TheDNAdamageresponseprotein53BP1utilizesitstandemtudordomaintorecognizedimethylatedlysine20onhistone(H4K20me2),amodificationassociatedwithdouble-strandDNAbreaks.UNC-2170,identifiedbyscreening,wasfoundtobeauMligandfor53BP1whichalsodemonstratedatleast17-foldselectivityfor53BP1overothermethyllysinebindingproteins.Thecompoundfunctionsasa53BP1antagoNISTincelllysatesandsuppressesclassswitchrecombinationinwholecells,aprocessrequiringafunctioning53BP1tudordomain.
PhysicalProperties:Whitepowder
MW=349.7C14H21BrN2O•HCl
Analysis:>98%(TLC);NMR(Conforms)
Solubilization:MaybedissolvedinDMSO(40mg/ml);orwater(50mg/ml)
Storage:Storedesiccatedassuppliedat-20°Cforupto2years.Storesolutionsat-20°Cforupto3months.
Amount:5mg