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reactionbiology(优势品牌)
主营:主营:分子类,蛋白类,抗体类,生化类试剂
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商品详细反应生物学/MOCENTOSTAT/EI-HDC-015
反应生物学/MOCENTOSTAT/EI-HDC-015
反应生物学/MOCENTOSTAT/EI-HDC-015
商品编号: EI-HDC-015
品牌: reactionbiology
市场价: ¥1740.00
美元价: 1044.00
产地: 美国(厂家直采)
公司:
产品分类: 反应底物
公司分类: Reaction_substrate
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Mocetinostathttps://reactionbiology-com.3dcartstores.com/admin/iteminfo.asp?catid=311&pannel=1Induceshyperacetylationofhistones,inducesexpressionofthetumorsuppressorp21WAF1andinhibitsproliferationofhumancancercells.Displaysantifibroticeffectsinischemicheartfailure.Attenuatesthedevelopmentofhypersensitivityinmodelsofneuropathicpain.Activeinvivo.Amount:5mgPhysicalProperties:Off-whitecrystallinepowder

MW=396.4C23H20N6O

Analysis:>98%(HPLC);NMR(Conforms)

Solubilization:MaybedissolvedinDMSO(25mg/ml)

Storage:Storedesiccatedatambienttemperatureforupto2years.Storesolutionsat-20°Cforupto2months.

品牌介绍
Reaction Biology描述: 人类重组EZH2incomplexwithhumanrecombinantsEED.TotalcomplexMWis228.7kDa.Allproteinsarefull长度(residue2throughC末端)也是全美-expressedinaninsectcell / baculovirusexpressionsystem.TheEEDsubunitincorporatesanN-terminalStrepandFlag-tagandallothersincludeanN-terminalHis-tag.CatalyzesthetransferofmethylgroupsfromS腺苷-L-甲硫氨酸(SAM)tothee-aminofunctionofproteinL-lysineresidues,specificallylysine-27ofhistoneH3( H3K27)。在开发过程中,Polycomb Repressive Complex 2(PRC2)是主要的甲基转移酶对IBL的反应eforgeneratingtrimethylatedhistoneH3lysine-27(的H3K27me3),anepigeneticmarkessentialforprogrammedrepressionofgeneexpression1-5.EZH2,whichincludesaSETmethyltransferasedomain,isthecatalyticsubunitofPRC21,6.ThecoreofthecatalyticcomplexincludesEZH2,EED,SUZ12andRbAp48,whileadditionofAEBP2significantlyenhancesthemethyltransferaseactivityofthecomplex(> 3×)6.EZH2isoverexpressedinawiderangeofhumancancersanditsoverexpressioncancorrelatewithtumorprogression,increasedmetastasisandpoorprognosis(seereview7).DepletionofEZH2and / orotherPRC2componentscaninhibitgrowthorinduceapoptosisincancercells6,8-10.Consequently,EZH2isconsideredapromisingtargetforthedevelopmentofanti -癌症疗法11 存取编号: EZH2NM_001203247,EEDNM_003797,SUZ12NM_015355 包括酰胺酸:EZH22-746,EED2-441,SUZ122-739 标记(S):EEDhasanN末端链霉菌标记标签,其他所有N末端His标签 分子量:228.7kDa EXPRESSIONSYSTEM :昆虫细胞/杆状病毒 SUPPLIEDAS:Solutionofpurifiedrecombinantproteinin20mMTris盐酸,pH8,150mMNaCl,2mMMgCl 2,2mMDTT,20%甘油(w / v),0.01%NP-40asdeterminedbyOD 280。 储存:-70°C。在使用前应迅速融化并储存。应保留未使用的未稀释蛋白质,例如干燥/冰乙醇液中的氮。尽可能减少冻融/解冻,但不建议使用稀释体积太小(<5µl)的稀释蛋白质。