苏州蚂蚁淘生物科技有限公司是专业从事生物技术产品销售的高科技企业,是国内生物试剂、仪器、消耗品领域的知名企业之一。起发公司自成立以来,连续2年高速成长。公司的发展目标是建成专业从事生物技术产品销售、生产与开发的一流公司。
Reaction Biology详细产品列表:
货号 | 产品 | 价格(美元) |
HMT-11-376 | ASH1L (His) Methyltransferase | 325 |
DMT-21-124 | DNMT1 | 450 |
DMT-21-125 | DNMT3a Methyltransferase | 450 |
DMT-21-126 | DNMT3b | 450 |
HMT-11-101 | DOT1L Methyltransferase | 395 |
HMT-25-115 | EZH1 Complex | 450 |
HMT-25-114 | EZH2 Complex | 799 |
HMT-25-173 | EZH2-Y641F Complex | 799 |
HMT-11-102 | G9a Methyltransferase (GST) (aa 786-1210) | 299 |
HMT-11-245 | G9a Methyltransferase (His) (aa 913-1193) | 299 |
HMT-12-104 | G9a/GLP Complex Methyltransferase | 325 |
HMT-11-103 | GLP Methyltransferase Protein | 299 |
HMT-15-105 | MLL1 Complex | 499 |
HMT-15-106 | MLL2 Complex | 499 |
HMT-15-107 | MLL3 Complex | 499 |
HMT-15-108 | MLL4 Complex | 499 |
MT-11-359 | NNMT (GST) (Nicotinamide N-Methyltransferase) | 299 |
MT-11-358 | NNMT (His) (Nicotinamide N-Methyltransferase) | 299 |
HMT-11-319 | NRMT1 (GST) | 325 |
HMT-21-139 | NSD1 Methyltransferase | 450 |
HMT-21-138 0 | NSD2 (His) Methyltransferase | 450 |
HMT-21-122 | NSD2 Methyltransferase | 550 |
HMT-11-377 | NSD2 SET (His) | 325 |
HMT-21-159 | NSD2-E1099K Methyltransferase | 599 |
HMT-11-378 | NSD2-E1099K-SET (His) | 325 |
HMT-21-181 | NSD2-T1150A Methyltransferase | 450 |
HMT-11-379 | NSD2-T1150A-SET (His) | 325 |
HMT-11-132 | NSD3 Methyltransferase | 325 |
HMT-21-348 | PRDM2 Methyltransferase | 325 |
HMT-21-152 | PRDM9 Methyltransferase | 450 |
HMT-11-119 | PRMT1 Methyltransferase | 325 |
HMT-11-113 | PRMT3 Methyltransferase | 325 |
HMT-11-120 | PRMT4 Methyltransferase | 399 |
HMT-21-172 | PRMT5 Methyltransferase | 450 |
HMT-22-434 | PRMT5(C449S)/MEP50 | 799 |
HMT-22-148 | PRMT5/MEP50 Complex | 799 |
HMT-11-121 | PRMT6 Methyltransferase (GST) | 325 |
HMT-21-380 | PRMT6 Methyltransferase (His) | 325 |
HMT-21-382 | PRMT7 (His) | 450 |
HMT-11-135 | PRMT8 Methyltransferase | 325 |
MT-11-356 | s-COMT (His) (Soluble Catechol-O-Methyltransferase) | 299 |
MT-11-357 | s-COMT (V108M) (His) (Soluble Catechol-O-Methyltransferase) | 299 |
HMT-15-116 | SET1A Complex (5-subunits) | 499 |
HMT-15-117 | SET1B Complex (5-subunits) | 499 |
HMT-11-133 | SET7/9 Methyltransferase | 299 |
HMT-11-476 | SET8 (GST) | 299 |
HMT-11-118 | SET8 Methyltransferase | 299 |
HMT-11-128 | SETD2 (GST) Methyltransferase | 299 |
HMT-11-129 | SETD2 (His) Methyltransferase | 299 |
HMT-11-110 | SMYD2 Methyltransferase | 325 |
HMT-11-111 | SUV39H1 Methyltransferase | 299 |
HMT-11-418 | SUV39H2 (GST) Methyltransferase | 299 |
HMT-11-112 | SUV39H2 (His) Methyltransferase | 299 |
HMT-21-149 | SUV420H1-tv1 Methyltransferase | 450 |
HMT-21-150 | SUV420H1-tv2 Methyltransferase | 450 |
HMT-21-349 | SUV420H2 Methyltransferase | 325 |
HMT-14-109 | WRAD2 | 375 |
HMT-14-438 | (H3.3-H4)2 Tetramer | 325 |
HMT-35-435 | Core Histones (Chicken) | 250 |
HMT-11-184 | Fibrillarin (GST) | 325 |
HMT-11-183 | Fibrillarin (His) | 325 |
HMT-11-137 | GST-GAR | 299 |
HMT-12-316 | H2A/H2B dimers | 325 |
HMT-11-180 | Histone H1.0 | 50 |
HMT-11-146 | Histone H2A | 50 |
HMT-11-147 | Histone H2B | 50 |
HMT-11-134 | Histone H3.3 | 50 |
HMT-35-179 | Nucleosomes (Chicken Mono/Di) | 280 |
HMT-35-182 | Nucleosomes (Chicken Oligo/Poly H5 Enriched) | 280 |
Reaction Biology描述:
人类重组EZH2incomplexwithhumanrecombinantsEED.TotalcomplexMWis228.7kDa.Allproteinsarefull长度(residue2throughC末端)也是全美-expressedinaninsectcell / baculovirusexpressionsystem.TheEEDsubunitincorporatesanN-terminalStrepandFlag-tagandallothersincludeanN-terminalHis-tag.CatalyzesthetransferofmethylgroupsfromS腺苷-L-甲硫氨酸(SAM)tothee-aminofunctionofproteinL-lysineresidues,specificallylysine-27ofhistoneH3( H3K27)。在开发过程中,Polycomb Repressive Complex 2(PRC2)是主要的甲基转移酶对IBL的反应eforgeneratingtrimethylatedhistoneH3lysine-27(的H3K27me3),anepigeneticmarkessentialforprogrammedrepressionofgeneexpression1-5.EZH2,whichincludesaSETmethyltransferasedomain,isthecatalyticsubunitofPRC21,6.ThecoreofthecatalyticcomplexincludesEZH2,EED,SUZ12andRbAp48,whileadditionofAEBP2significantlyenhancesthemethyltransferaseactivityofthecomplex(> 3×)6.EZH2isoverexpressedinawiderangeofhumancancersanditsoverexpressioncancorrelatewithtumorprogression,increasedmetastasisandpoorprognosis(seereview7).DepletionofEZH2and / orotherPRC2componentscaninhibitgrowthorinduceapoptosisincancercells6,8-10.Consequently,EZH2isconsideredapromisingtargetforthedevelopmentofanti -癌症疗法11
存取编号:EZH2NM_001203247,EEDNM_003797,SUZ12NM_015355
包括酰胺酸:EZH22-746,EED2-441,SUZ122-739
标记(S):EEDhasanN末端链霉菌标记标签,其他所有N末端His标签
分子量:228.7kDa
EXPRESSIONSYSTEM:昆虫细胞/杆状病毒
SUPPLIEDAS:Solutionofpurifiedrecombinantproteinin20mMTris盐酸,pH8,150mMNaCl,2mMMgCl2,2mMDTT,20%甘油(w / v),0.01%NP-40asdeterminedbyOD280。
储存:-70°C。在使用前应迅速融化并储存。应保留未使用的未稀释蛋白质,例如干燥/冰乙醇液中的氮。尽可能减少冻融/解冻,但不建议使用稀释体积太小(<5µl)的稀释蛋白质。
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